TetraLogic Pharmaceuticals, a biopharmaceutical company developing novel small molecule Smac mimetic drugs to treat cancer, today announced presentations of new data on its Smac mimetic drug candidate TL32711 at the 2011 AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics in San Francisco. TL32711 is nearing completion of a single agent Phase 1 study in solid tumors and lymphomas and a Phase 1b five-arm combination clinical study in solid tumors.
In a poster entitled “Phase 1 PK/PD Analysis of the Smac Mimetic TL32711 Demonstrates Potent and Sustained cIAP1 Suppression in Patient PBMC and Tumor Biopsies” (Abstract # A25), the degradation and suppression of cIAP1 was analyzed as part of the single agent Phase 1 study. The data demonstrated that TL32711 causes potent and sustained suppression of inhibitor of apoptosis protein cIAP1 in patient peripheral blood mononuclear cells (PBMCs) and tumor biopsies over 7 days at tolerable dose levels with evidence of apoptosis pathway activation and promising early signs of anti-tumor activity in patients.
In a poster entitled “Dose scheduling and efficacy analysis of the Smac mimetic TL32711 in primary melanoma tumor xenotransplant models” (Abstract # A225), tumor growth inhibition was observed in primary melanoma tumor xenografts following treatment with single agent TL32711. Combining TL32711 with carboplatin and paclitaxel resulted in a further enhancement in anti-tumor efficacy with tumor regressions without any marked changes in tolerability.